What UI/UX best practices are applicable in the case of RWAs?

Recently, we have started work on a Rich Web Application (RWA) project. In the process of choosing a suitable UI framework, and web components. Is there a difference between choosing design patterns for a RWA and a standard website? If yes, what are those differences?

We have many UI frameworks on the market, UI/UX best practices and design patterns for the web. If a solution (e.g. Bootstrap) is widely accepted and it has been used, could we consider such solution suitable for a RWA?

Thanks in advance.