Web application Design – using full screen width

With today large screen resolution (1920 screen width rules now), I need to decide between using the full width of the screen (liquid) versus fixed with (padding with white margin over 1366px for example).

Our main a web applications has tables, lists, complex forms and is designed to be used mainly on organisation Desktops.

While using all screen width can be great in terms of complex layouts such as master-detail, many charts and tables, I am aware that elements that are in the far left/right corners can be ignored easily. I see that many web apps goes for the full screen width (slack, Asana, Jira, Salesforce). Any ideas, thoughts or references regards such decision?

Thanks, Iris--