Using alternative TLDs in email addresses

If you have a non-standard TDL, such as .cc or .io, used in an email address do those you tell it to act in a confused or surprised manner when you give it out?

The question is specific to .io domains but could be applied to any TLD other than .com and your default country domain.

The less common domains obviously have more choice of premium words which is helpful however I am wondering if the benefit is offset by the confusion of the lesser known domain extensions.

I have seen an example of someone giving out a .co address, where the recipient said ".co what..." as they were clearly expecting .co.uk.