Resources on generating a UI according to a set of metrics or an algorithm?

I understand that I am asking a much more reaserch/academic oriented question and may be out of the scope of this site but I have searched tirelessly and I cannot find any available resources.

I am looking for resources on how can a user interface can be deduced in a scientific manner. I understand the need for certain standards such as ISO's to measure usability and iterativly improve an existing interface. But these methods generally focus on usability studies and heuristic approaches, which rely on having available participants.

I am looking for more information or examples on how algorithms were used to improve an interface or how an algorithm could be used to create one.

Any ideas or help would be appreciated.