Override browser shortcuts

The company that I work for is suggesting that we override browser shortcut CTRL + S in our single page app to apply changes (save). It's a complex editor so autosave would not work for this particular instance, and since it's used for data entry keyboard shortcuts are a must have.

I have searched all over, including this site, and keep finding conflicting reports. There are plenty of articles that say it's a bad idea, but then I see big names like Jira, Docusign, Prezi, all using CTRL + S to save.

It seems like a bad idea to me, but I would like to hear your thoughts before going toe-to-toe with the higher ups.