Is using the @ (at sign) an acceptible replacement for the word "at" for screen readers?

When thinking foremost about accessibility, is there any issue in replacing the word "at" with the @ (at sign)?

Example 1: "meet me @ 2pm" vs. "meet me at 2pm"

Example 2: "Topic@Company" vs. "Topic @ Company" vs. "Topic at Company"

Does this confuse screen readers or users—perhaps make them think an email address is coming? I couldn't find any resources on the topic.