Is it possible to separate a subject from context?

This is a bit of a theoretical but I wonder if its meaningfully possible to separate the context from the subject when studying the context of a particular subject.

For example, would there be a meaningful difference if I worked with UX and studied the context of a water-purification plant worker without knowing anything about chemistry or the concepts of water purification beyond basics? My position is that these "details" and the subject (chemistry) are needed and are part of that context that is used to inform the user experience and creating appropriate interactions and/or interfaces.