Inclusive notification scheme incorporated into design systems

It seems like the standard RED, YELLOW, GREEN and BLUE colours are used in notification schemes/styles in the most popular development frameworks like Material.io and Bootstrap.

Of course, colours shouldn't be used by itself as a UI design element, but the standardization of the RED and GREEN combination in a colour palette reduces the effectiveness of other design elements to distinguish between different statuses in the notification scheme/style.

Are there examples of design systems or development frameworks where the notification scheme/style takes into consideration of the common issues:

  • Red and green colour blindness (and other forms of colour blindness)
  • A low contrast (i.e. bright or feint) yellow
  • simple and clear iconography to complement the notification colour scheme