Guidelines for designing toolbars [closed]

We are looking to build a Web Application for use by doctors. This web application is closer to a design studio type of application where there is a central "work area" that the user will focus on.

We also need a sidebar and a toolbar to house options and different functions as well as data. I would like to optimize the "work area" to have most amount of space.

Was looking for pointers for how to design toolbars for such an Web Application. Any resources that would help with this?