Are there guidelines on interaction design to prevent repetitive strain injuries for users?

With so much of the digital and web applications focusing on the mobile platform, and so much of the revenues from companies generated from 'edutainment' related applications, I am wondering what the future impact of young people interacting with mobile applications and being asked to develop interactions that involve a lot of repetitive motions (e.g. mobile games that involve constant tapping or rotation of thumbs from virtual controls).

Even though there are probably some guidelines for physical products for children regarding ergonomics and there are also methods for preventing injury in music (like the Alexander Technique), I think that this is still a very immature area for digital design and perhaps more needs to be done to help improve ethical design practices.

The question is, are there known or published guidelines for designing digital interfaces that help reduce the physical impact on users (e.g. Augmented Reality improvements to reduce dizziness and motion sickness), especially when it comes to repetitive motion that can cause RSI?